Знаков)

headache

Less common

Acid or sour stomach

belching

difficulty in moving

heartburn

indigestion

joint pain

muscle aching or cramping

muscle pains or stiffness

nausea

rash

stomach discomfort, upset, or pain

trouble sleeping

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

swollen joints

For Healthcare Professionals

Applies to verapamil: compounding powder, intravenous solution, oral capsule extended release, oral tablet, oral tablet extended release

Gastrointestinal

Constipation due to verapamil (the active ingredient contained in Calan) appears to be related to a delay of colonic transit and not to an effect on upper gastrointestinal transit.[Ref]

Gastrointestinal side effects have included constipation (up to 11.7%), nausea (up to 2.7%), dyspepsia (up to 2.7%), and diarrhea (up to 2.4%). Nausea (0.9%) and abdominal discomfort (0.6%) have been reported with intravenous verapamil. Nonobstructive, paralytic ileus (reversible upon discontinuation) has been reported infrequently. Diarrhea, dry mouth, gastrointestinal distress, and gingival hyperplasia have been reported during open trials/postmarketing experience.[Ref]

Cardiovascular

Cardiovascular side effects have included hypotension (up to 2.5%), new or worsened congestive heart failure (CHF) or pulmonary edema (negative inotropism; 1.8%), bradycardia (heart rate less than 50/minute; 1.4%), atrioventricular (AV) block (first-degree; up to 1.7%), AV block (total first-, second-, and third-degree; 1.2%), AV block (second- and third-degree; 0.8%), and postural hypotension (up to 0.4%). Symptomatic hypotension (1.5%), bradycardia (1.2%), and severe tachycardia (1%) have been reported with intravenous verapamil (the active ingredient contained in Calan) In studies related to control of